"All of creation cares not whether you live or die."
Darksiders II features four playable difficulties, each harder then the next.
The mode is rewarded after completing the game is only available when starting a new game, meaning that it is not available in the New Game Plus mode. While similar to the Apocalyptic difficulty, it does feature a major difference. Upon one's death, all player data for that save will abruptly be wiped, forcing players to restart the game from the beginning. In other words, Death only has one life.
- Unlike other difficulties, Nightmare modes does not noticeably increase difficulty, nor does it provide an achievement or trophy upon its completion.
- Completing the game on Apocalyptic will also unlock the achievements or trophies for lower difficulties.
- The remastered version of the game on Xbox One, PS4 and PC named Darksiders II Deathinitive Edition has a new difficulty far harder than Apocalyptic called Deathinitive.